Ozempic follows a low and slow titration schedule to minimize gastrointestinal side effects (nausea, vomiting).
| Time Period | Dose | Frequency | Purpose | Pen Color | | :--- | :--- | :--- | :--- | :--- | | | 0.25 mg | Once weekly | Initiation – No glycemic benefit; builds tolerance | Red | | Weeks 5–8 | 0.5 mg | Once weekly | Therapeutic start – Initial A1c reduction | Red | | Weeks 9–12+ | 1.0 mg | Once weekly | Standard therapeutic dose | Blue | | If needed (after 1.0 mg x 4 weeks) | 2.0 mg | Once weekly | Maximum approved dose for T2DM | Gray | Note: Do not skip the 0.25 mg starter dose. Starting directly at 0.5 mg or higher significantly increases severe nausea and vomiting risk. 2. Ozempic Pen Identification & Dose Selection Chart Each pen delivers a specific set of doses. Turning the dial clicks to the exact mg. ozempic doses chart